I’ve just been trying to play Bioshock for the first time on my recently bought Windows 7 machine, and have been having issues with the audio. All the startup sounds and cutscene movies work perfectly, however there was no sound in game or when clicking menu buttons.

After lots of searching in forums and trying numerous suggested solutions (running the .exe in Vista/XP compatibility modes etc), I’ve found the solution that works on my PC. The issue appears to be that Stereo Mixing was disabled by default.

Here’s a link to a support page with instructions on how to fix this:

http://support.take2games.com/help/take2/take2_games/q632

Hope that is of some help to someone!

*Mumbles something about why I switched to console gaming for many years*

 

[Edit: I had massive issues with audio in GTA IV a while back too. Incredibly stuttery/crackly sound in game, making it completely unplayable. This fix appears to have resolved that issue too.]